Desmopressin is a drug similar to a hormone found naturally in the body. Desmopressin is indicated as an antidiuretic replacement therapy in patients who have had problems with involuntary nighttime urination, or bedwetting. Desmopressin can be used alone or as adjunct therapy to behavioral conditioning. Desmopressin is also indicated for patients who have recently suffered a head trauma and suffer from excessive urination due to that trauma.
Desmopressin takes about three weeks before results begin to be seen in patients who are monosymptomatic. However, the drug is generally only effective for patients if nighttime bedwetting is the patient's only medical problem. If there are other epidemiological or hormonal factors at work, then desmopressin is effective in only a small percentage of patients.
In December 2007 the FDA released an
alert about desmopressin stating that certain children on desmopressin nasal spray are at extreme risk for developing severe water intoxication and seizures because of the medication. Water intoxication (hyponatremia) is a very serious condition in which water in blood plasma shifts to brain cells, causing stupor, diminished reflexes, headaches, and vomiting.
If you are taking desmopressin and are also at risk for hyponatremia, then you may wish to speak to your physician, as patients with a history of hyponatremia are at risk of developing complications on desmopressin. There have been two reported deaths as a result of desmopressin use.
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